The human endothelin-1 (ET-1) gene under the control of its natural promoter was transferred
into the germline of mice. The transgene was expressed predominantly in the brain, lung, …

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Background About 1% of white populations are homozygous carriers of an allele of the gene
for the CC chemokine receptor 5 (CCR5) with a 32 bp deletion (CCR5Δ32), which leads to …

Chronic kidney disease (CKD) has a high prevalence in the general population and is
associated with high mortality; a need therefore exists for better biomarkers for diagnosis, …

Importance Neonates born to overweight or obese women are larger and at higher risk of
birth complications. Many maternal obesity-related traits are observationally associated with …

The pulmonary endothelin (ET) system has been implicated in the pathogenesis of chronic
lung diseases such as pulmonary hypertension, asthma, chronic obstructive lung disease, …

Cyclosporine (CsA) nephrotoxicity is a severe complication in organ transplantation because
it leads to impaired renal function and chronic allograft nephropathy, which is a major …

Background: The need for an improved treatment for diabetic nephropathy is greatest in
patients who do not adequately respond to angiotensin II receptor blockers (ARBs). This study …

Vitamin D, either in its D 2 or D 3 form, is essential for normal human development during
intrauterine life, kidney function and bone health. Vitamin D deficiency has also been linked to …

Background & Aims: Endothelin 1 induces contraction, proliferation, and collagen synthesis
of hepatic stellate cells in vitro, which may be mediated via the endothelin A receptor. It is …