Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial

RH Green, CE Brightling, S McKenna, B Hargadon… - The Lancet, 2002 - thelancet.com
Background Treatment decisions in asthma are based on assessments of symptoms and
simple measures of lung function, which do not relate closely to underlying eosinophilic airway …

[HTML][HTML] Mepolizumab and exacerbations of refractory eosinophilic asthma

P Haldar, CE Brightling, B Hargadon… - New England journal …, 2009 - Mass Medical Soc
Background Exacerbations of asthma are associated with substantial morbidity and mortality
and with considerable use of health care resources. Preventing exacerbations remains an …

[HTML][HTML] Evidence of a role of tumor necrosis factor α in refractory asthma

MA Berry, B Hargadon, M Shelley… - … England Journal of …, 2006 - Mass Medical Soc
Background The development of tumor necrosis factor α (TNF-α) antagonists has made it
feasible to investigate the role of this cytokine in refractory asthma. Methods We measured …

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma

…, KM Vannella, CA Butler, B Hargadon… - Science translational …, 2015 - science.org
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n = 51), …

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

…, CM Ohri, E Doran, C Butler, B Hargadon… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the
pathophysiology of asthma through 2 distinct pathways: a TSLP–OX40 ligand (OX40L)–T cell axis …

IgE Sensitization to Aspergillus fumigatus Is Associated with Reduced Lung Function in Asthma

A Fairs, J Agbetile, B Hargadon, M Bourne… - American journal of …, 2010 - atsjournals.org
Rationale: The importance of Aspergillus fumigatus sensitization and colonization of the
airways in patients with asthma is unclear. Objectives: To define the relationship between the …

Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis

…, CE Brightling, A Singapuri, B Hargadon… - Journal of allergy and …, 2014 - jacionline.org
To the Editor: Treatment with the neutralizing monoclonal anti–IL-5 antibody mepolizumab
for 12 months results in a significant reduction in exacerbation frequency and eosinophilic …

[HTML][HTML] Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre …

…, G Gainsborough, T Grandison, B Hargadon… - The Lancet …, 2021 - thelancet.com
Background Asthma treatment guidelines recommend increasing corticosteroid dose to
control symptoms and reduce exacerbations. This approach is potentially flawed because …

Diagnosis of COVID-19 by exhaled breath analysis using gas chromatography–mass spectrometry

…, L Carr, ASD Dasi, B Hargadon… - ERJ open …, 2021 - Eur Respiratory Soc
Background The ongoing coronavirus disease 2019 (COVID-19) pandemic has claimed
over two and a half million lives worldwide so far. Severe acute respiratory syndrome …

Lung computational models and the role of the small airways in asthma

…, A Bell, A Singapuri, B Hargadon… - American journal of …, 2019 - atsjournals.org
Rationale: Asthma is characterized by disease within the small airways. Several studies have
suggested that forced oscillation technique–derived resistance at 5 Hz (R5) − resistance at …