User profiles for Bhairav Paleja
Bhairav PalejaSenior Scientist Verified email at vantage-research.net Cited by 1623 |
Metformin as adjunct antituberculosis therapy
The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential
new approach to TB therapy is to augment protective host immune responses. We report …
new approach to TB therapy is to augment protective host immune responses. We report …
[HTML][HTML] Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic …
conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic …
[HTML][HTML] Inhibiting interleukin 11 signaling reduces hepatocyte death and liver fibrosis, inflammation, and steatosis in mouse models of nonalcoholic steatohepatitis
Background & Aims We studied the role of interleukin 11 (IL11) signaling in the pathogenesis
of nonalcoholic steatohepatitis (NASH) using hepatic stellate cells (HSCs), hepatocytes, …
of nonalcoholic steatohepatitis (NASH) using hepatic stellate cells (HSCs), hepatocytes, …
Functionally diverse human T cells recognize non-microbial antigens presented by MR1
10.7554/eLife.24476.001 MHC class I-related molecule MR1 presents riboflavin- and folate-related
metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 …
metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 …
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis
…, MB Marzuki, X Lu, TW Foreman, B Paleja… - Science …, 2017 - science.org
Mycobacterium tuberculosis (Mtb) executes a plethora of immune-evasive mechanisms,
which contribute to its pathogenesis, limited efficacy of current therapy, and the emergence of …
which contribute to its pathogenesis, limited efficacy of current therapy, and the emergence of …
Fibroblast‐specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease
Repetitive pulmonary injury causes fibrosis and inflammation that underlies chronic lung
diseases such as idiopathic pulmonary fibrosis (IPF). Interleukin 11 (IL11) is important for …
diseases such as idiopathic pulmonary fibrosis (IPF). Interleukin 11 (IL11) is important for …
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts
…, BL George, U Altunoglu, K Ghosh, BS Paleja… - …, 2021 - academic.oup.com
Objectives Interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts from patients
with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically linked with …
with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically linked with …
The Extended Polydimensional Immunome Characterization (EPIC) web-based reference and discovery tool for cytometry data
To the Editor—The proliferation of single-cell datasets from mass cytometry has driven the
need for an open registry capable of hosting data from different laboratories, correcting for …
need for an open registry capable of hosting data from different laboratories, correcting for …
[HTML][HTML] Proinflammatory IL-17 pathways dominate the architecture of the immunome in pediatric refractory epilepsy
Drug refractory epilepsy (RE) is a chronic neurological disease with varied etiology that
represents a group of patients whose seizures do not respond to antiepileptic drugs. The …
represents a group of patients whose seizures do not respond to antiepileptic drugs. The …
[HTML][HTML] Microchip-based ultrafast serodiagnostic assay for tuberculosis
Access to point-of-care (POC), rapid, inexpensive, sensitive, and instrument-free tests for the
diagnosis of tuberculosis (TB) remains a major challenge. Here, we report a simple and low-…
diagnosis of tuberculosis (TB) remains a major challenge. Here, we report a simple and low-…