The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential
new approach to TB therapy is to augment protective host immune responses. We report …

Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic …

Background & Aims We studied the role of interleukin 11 (IL11) signaling in the pathogenesis
of nonalcoholic steatohepatitis (NASH) using hepatic stellate cells (HSCs), hepatocytes, …

10.7554/eLife.24476.001 MHC class I-related molecule MR1 presents riboflavin- and folate-related
metabolites to mucosal-associated invariant T cells, but it is unknown whether MR1 …

Mycobacterium tuberculosis (Mtb) executes a plethora of immune-evasive mechanisms,
which contribute to its pathogenesis, limited efficacy of current therapy, and the emergence of …

Repetitive pulmonary injury causes fibrosis and inflammation that underlies chronic lung
diseases such as idiopathic pulmonary fibrosis (IPF). Interleukin 11 (IL11) is important for …

Objectives Interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts from patients
with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically linked with …

To the Editor—The proliferation of single-cell datasets from mass cytometry has driven the
need for an open registry capable of hosting data from different laboratories, correcting for …

Drug refractory epilepsy (RE) is a chronic neurological disease with varied etiology that
represents a group of patients whose seizures do not respond to antiepileptic drugs. The …

Access to point-of-care (POC), rapid, inexpensive, sensitive, and instrument-free tests for the
diagnosis of tuberculosis (TB) remains a major challenge. Here, we report a simple and low-…