Background & Aims We studied the role of interleukin 11 (IL11) signaling in the pathogenesis
of nonalcoholic steatohepatitis (NASH) using hepatic stellate cells (HSCs), hepatocytes, …

Repetitive pulmonary injury causes fibrosis and inflammation that underlies chronic lung
diseases such as idiopathic pulmonary fibrosis (IPF). Interleukin 11 (IL11) is important for …

Objectives Interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts from patients
with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically linked with …

NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an
intracellular pattern recognition receptor for microbial products. Here, we generated a Nlrp10 −…

… ’s trichrome staining of lung sections were described previously (3). Fibrosis scores in
Masson’s … Primary antibodies concentrations were then applied according to manufacturer’s …

The transformation of hepatic stellate cells (HSCs) into myofibroblasts is the defining pathobiology
in non-alcoholic steatohepatitis (NASH). Here we show that key NASH factors induce …

… We mapped this cohort’s data directly to EPIC for comparison with the panel B dataset (Fig. …
data, even with an antibody panel only partially matched to EPIC’s (Fig. 3c,d). This approach …

… P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by two-tailed Student’s t test. Exact P
values are provided in table S8. To identify the possible mechanism(s) underlying the restriction …

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