User profiles for Bharat Ravi Iyengar

Bharat Ravi Iyengar

University of Münster
Verified email at uni-muenster.de
Cited by 157

Neutral Models of De Novo Gene Emergence Suggest that Gene Evolution has a Preferred Trajectory

BR Iyengar, E Bornberg-Bauer - Molecular Biology and …, 2023 - academic.oup.com
New protein coding genes can emerge from genomic regions that previously did not contain
any genes, via a process called de novo gene emergence. To synthesize a protein, DNA …

[PDF][PDF] GroEL/S overexpression helps to purge deleterious mutations and reduce genetic diversity during adaptive protein evolution

BR Iyengar, A Wagner - Molecular Biology and Evolution, 2022 - academic.oup.com
Chaperones are proteins that help other proteins fold. They also affect the adaptive evolution
of their client proteins by buffering the effect of deleterious mutations and increasing the …

Systematic comparison of the response properties of protein and RNA mediated gene regulatory motifs

BR Iyengar, B Pillai, KV Venkatesh, CJ Gadgil - Molecular BioSystems, 2017 - pubs.rsc.org
We present a framework enabling the dissection of the effects of motif structure (feedback or
feedforward), the nature of the controller (RNA or protein), and the regulation mode (…

Bacterial Hsp90 predominantly buffers but does not potentiate the phenotypic effects of deleterious mutations during fluorescent protein evolution

BR Iyengar, A Wagner - Genetics, 2022 - academic.oup.com
Chaperones facilitate the folding of other (“client”) proteins and can thus affect the adaptive
evolution of these clients. Specifically, chaperones affect the phenotype of proteins via two …

Identification of novel circadian transcripts in the zebrafish retina

S Ramasamy, S Sharma, BR Iyengar… - Journal of …, 2019 - journals.biologists.com
High fecundity, transparent embryos for monitoring the rapid development of organs and the
availability of a well-annotated genome has made zebrafish a model organism of choice for …

Properties of compostite feedback-feedforward pulse generating motifs

BR Iyengar - bioRxiv, 2016 - biorxiv.org
Negative feedbacks and incoherent feedforward loops are known to give rise to a pulse in
response to a step change in the input. In this article, I present a study of composite motifs …

A direct experimental test of Ohno's hypothesis

L Mihajlovic, BR Iyengar, F Baier, I Barbier… - bioRxiv, 2023 - biorxiv.org
Gene duplication drives evolution by providing raw material for proteins with novel functions.
The oldest and historically most influential hypothesis about the evolutionary fate and …

How antisense transcripts can evolve to encode novel proteins

BR Iyengar, A Grandchamp, E Bornberg-Bauer - bioRxiv, 2023 - biorxiv.org
Protein coding features can emerge de novo in non coding transcripts, resulting in emer-
gence of new protein coding genes. Studies across many species show that a large frac- tion …

De novo ORFs are more likely to shrink than to elongate during neutral evolution.

MK Lebherz, BR Iyengar, E Bornberg-Bauer - bioRxiv, 2024 - biorxiv.org
For protein coding genes to emerge de novo from a non-genic DNA, the DNA sequence must
gain an open reading frame (ORF) and the ability to be transcribed. The newborn de novo …

[PDF][PDF] In search for multifunctional lncRNAs

BR Iyengar - bornberglab.org
Long non-coding RNAs (lncRNAs) were so named because at the time of their discovery,
no corresponding protein products were known. Despite the lack of evidence for translation, …