AI has the potential to dramatically affect nearly all aspects of oncology—from enhancing
diagnosis to personalizing treatment and discovering novel anticancer drugs. Here, we review …

Many cancer cells consume large quantities of glutamine to maintain TCA cycle anaplerosis
and support cell survival. It was therefore surprising when RNAi screening revealed that …

Patient-specific induced pluripotent stem cells (iPSCs) represent a novel system for
modeling human genetic disease and could provide a source of cells for large-scale drug-discovery …

Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical
phenotype. To define the biological features driving this phenotype, we performed an …

IRE1α-XBP1 signaling is emerging as a central orchestrator of malignant progression and
immunosuppression in various cancer types. Employing a computational XBP1s detection …

CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis.
We now show that elimination of CD95 or CD95L results in a form of cell death that is …

Dengue virus (DENV) infections are vectored by mosquitoes and constitute one of the most
prevalent infectious diseases in many parts of the world, affecting millions of people annually…

We describe Exome Cancer Test v1. 0 (EXaCT-1), the first New York State-Department of
Health-approved whole-exome sequencing (WES)-based test for precision cancer care. EXaCT…

To investigate changes in the tumor microenvironment (TME) during lung cancer progression,
we interrogate tumors from two chest computed tomography (CT)-defined groups. Pure …

Older age is a strong risk factor for several diseases, including cancer. The etiology and
biology of age-associated differences among cancers are poorly understood. To address this …