Monkeys serve as important model species for studying human diseases and developing
therapeutic strategies, yet the application of monkeys in biomedical researches has been …

Interpreting the mechanisms and principles that govern gene activity and how these genes
work according to -their cellular distribution in organisms has profound implications for …

Strategies that enhance the function of T cells are critical for immunotherapy. One negative
regulator of T-cell activity is ligand PD-L1, which is expressed on dentritic cells (DCs) or some …

Background Dynamic N 6 -methyladenosine (m 6 A) modification was previously identified as
a ubiquitous post-transcriptional regulation that affected mRNA homeostasis. However, the …

Recent genome-wide studies have revealed that the majority of the mouse genome is
transcribed as non-coding RNAs (ncRNAs) and growing evidence supports the importance of …

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the start of the pandemic, olfactory …

The olfactory nerve (ON) is the only cranial nerve exposed to the external environment.
Hence, it is susceptible to damage from head trauma, viral infection, inflammatory stimulation, …

Taking advantage of the multiplexable genome engineering feature of the CRISPR/Cas9
system, we sought to generate different kinds of immunodeficient mouse strains by embryo co-…

Co-injection of zygotes with Cas9 mRNA and sgRNA has been proven to be an efficient
gene-editing strategy for genome modification of different species. Genetic engineering in pigs …

CRISPR/Cas9-mediated programmed cell death protein 1 (PD-1) disruption in chimeric antigen
receptor (CAR) T cells could be an appealing choice to improve the therapeutic efficacy …