User profiles for Bianca Dumitrascu

Bianca Dumitrascu

Columbia University
Verified email at columbia.edu
Cited by 519

[HTML][HTML] In silico tissue generation and power analysis for spatial omics

EAG Baker, D Schapiro, B Dumitrascu, S Vickovic… - Nature …, 2023 - nature.com
As spatially resolved multiplex profiling of RNA and proteins becomes more prominent, it is
increasingly important to understand the statistical power available to test specific …

Deep learning for bioimage analysis in developmental biology

A Hallou, HG Yevick, B Dumitrascu… - Development, 2021 - journals.biologists.com
Deep learning has transformed the way large and complex image datasets can be processed,
reshaping what is possible in bioimage analysis. As the complexity and size of bioimage …

[HTML][HTML] Sparse multi-output Gaussian processes for online medical time series prediction

LF Cheng, B Dumitrascu, G Darnell, C Chivers… - BMC medical informatics …, 2020 - Springer
Background For real-time monitoring of hospital patients, high-quality inference of patients’
health status using all information available from clinical covariates and lab test results is …

netNMF-sc: leveraging gene–gene interactions for imputation and dimensionality reduction in single-cell expression analysis

R Elyanow, B Dumitrascu, BE Engelhardt… - Genome …, 2020 - genome.cshlp.org
Single-cell RNA-sequencing (scRNA-seq) enables high-throughput measurement of RNA
expression in single cells. However, because of technical limitations, scRNA-seq data often …

[HTML][HTML] Optimal marker gene selection for cell type discrimination in single cell analyses

B Dumitrascu, S Villar, DG Mixon… - Nature …, 2021 - nature.com
Single-cell technologies characterize complex cell populations across multiple data modalities
at unprecedented scale and resolution. Multi-omic data for single cell gene expression, in …

Pg-ts: Improved thompson sampling for logistic contextual bandits

B Dumitrascu, K Feng… - Advances in neural …, 2018 - proceedings.neurips.cc
We address the problem of regret minimization in logistic contextual bandits, where a learner
decides among sequential actions or arms given their respective contexts to maximize …

[HTML][HTML] Hypergraph factorization for multi-tissue gene expression imputation

…, CK Joshi, D Georgiev, P Lin, B Dumitrascu… - Nature machine …, 2023 - nature.com
Integrating gene expression across tissues and cell types is crucial for understanding the
coordinated biological mechanisms that drive disease and characterize homoeostasis. …

[HTML][HTML] Causal network inference from gene transcriptional time-series response to glucocorticoids

J Lu, B Dumitrascu, IC McDowell, B Jo… - PLoS computational …, 2021 - journals.plos.org
Gene regulatory network inference is essential to uncover complex relationships among gene
pathways and inform downstream experiments, ultimately enabling regulatory network re-…

Statistical tests for detecting variance effects in quantitative trait studies

B Dumitrascu, G Darnell, J Ayroles… - …, 2019 - academic.oup.com
Motivation Identifying variants, both discrete and continuous, that are associated with
quantitative traits, or QTs, is the primary focus of quantitative genetics. Most current methods are …

End-to-end training of deep probabilistic CCA on paired biomedical observations

G Gundersen, B Dumitrascu, JT Ash… - Proceedings of The …, 2020 - oar.princeton.edu
Medical pathology images are visually evaluated by experts for disease diagnosis, but the
connection between image features and the state of the cells in an image is typically unknown…