To investigate the immune response and mechanisms associated with severe coronavirus
disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal …

The SARS ‐CoV‐2 pandemic affecting the human respiratory system severely challenges
public health and urgently demands for increasing our understanding of COVID ‐19 …

Blood formation is believed to occur through stepwise progression of haematopoietic stem
cells (HSCs) following a tree-like hierarchy of oligo-, bi-and unipotent progenitors. However, …

In coronavirus disease 2019 (COVID-19), hypertension and cardiovascular diseases are
major risk factors for critical disease progression. However, the underlying causes and the …

Efficient preparation of high-quality sequencing libraries that well represent the biological
sample is a key step for using next-generation sequencing in research. Tn5 enables fast, …

Autosomal-dominant brachydactyly type E (BDE) is a congenital limb malformation
characterized by small hands and feet predominantly as a result of shortened metacarpals and …

Chromatin organization is essential for defining transcription units and maintaining genomic
integrity in eukaryotes. In this study, we found that deletion of the Schizosaccharomyces …

The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges
public health and urgently demands for increasing our understanding of COVID-19 …

Cryptic transcription is widespread and generates a heterogeneous group of RNA molecules
of unknown function. To improve our understanding of cryptic transcription, we investigated …

Mesomelic dysplasia Kantaputra type (MDK) is characterized by marked mesomelic shortening
of the upper and lower limbs originally described in a Thai family. To identify the cause of …