A critical component in the interpretation of systems-level studies is the inference of enriched
biological pathways and protein complexes contained within OMICs datasets. Successful …

The heart is formed from cardiogenic progenitors expressing the transcription factors Nkx2-5
and Isl1 (refs 1 and 2 ). These multipotent progenitors give rise to cardiomyocyte, smooth …

Recently, as more and more social network data has been published in one way or another,
preserving privacy in publishing social network data becomes an important concern. With …

Exchange rates, like many other financial time series, display substantial heteroscedasticity.
This poses obstacles in detecting trends and changes. Understanding volatility becomes …

The origins and developmental mechanisms of coronary arteries are incompletely
understood. We show here by fate mapping, clonal analysis, and immunohistochemistry that …

The inability to repair DNA damage properly in mammals leads to various disorders and
enhanced rates of tumour development. Organisms respond to chromosomal insults by …

Background One of the global targets for non-communicable diseases is to halt, by 2025,
the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to …

The hypothesis that cancer is driven by tumour-initiating cells (popularly known as cancer
stem cells) has recently attracted a great deal of attention, owing to the promise of a novel …

High blood pressure is one of the most important risk factors for ischaemic heart disease,
stroke, other cardiovascular diseases, chronic kidney disease and dementia. Mean blood …

Background Raised blood pressure is an important risk factor for cardiovascular diseases
and chronic kidney disease. We estimated worldwide trends in mean systolic and mean …