K-RAS is frequently mutated in cancers, and its overactivation can lead to oncogene-induced
senescence (OIS), a barrier to cellular transformation. Feedback onto K-RAS limits its …

Genetic manipulation is a powerful tool to establish the causal relationship between a
genetic lesion and a particular pathological phenotype. The rise of CRISPR/Cas9 genome-…

Evaluating the relationship between the human gut microbiome and disease requires
computing reliable statistical associations. Here, using millions of different association modeling …

K-Ras frequently acquires gain-of-function mutations (K-Ras G12D being the most common)
that trigger significant transcriptomic and proteomic changes to drive tumorigenesis. …

Epidemiological studies have reported conflicting results between folate intake and bladder
cancer risk. We conducted a meta-analysis of epidemiological studies published between …

An allosteric network formed by interaction between lysine 104 and residues in the switch-II
domain is required for KRAS oncogenicity, which could be exploited for developing …

Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution
of this important layer of gene regulation to tissue homeostasis in adult animals remains …

Background: Macau is a densely populated international tourist city. Compared to most
tensely populated countries/territories, the prevalence and mortality of COVID-19 in Macau are …

Butterfly (a cyclic graph motif) counting is a fundamental task with many applications in graph
analysis, which aims at computing the number of butterflies in a large graph. With the rapid …

Background Heart failure with midrange ejection fraction (HFmrEF) has been recently
acknowledged as a separate phenotype, but metabolomics evaluation of this subtype remains …