User profiles for Bingfei Yu
 | Bingfei YuAssistant Professor @USC Verified email at usc.edu Cited by 3493 |
Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation
Dynamic changes in the expression of transcription factors (TFs) can influence the specification
of distinct CD8 + T cell fates, but the observation of equivalent expression of TFs among …
of distinct CD8 + T cell fates, but the observation of equivalent expression of TFs among …
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
Tissue-resident memory CD8 + T (T RM ) cells are found at common sites of pathogen
exposure, where they elicit rapid and robust protective immune responses 1 , 2 . However, the …
exposure, where they elicit rapid and robust protective immune responses 1 , 2 . However, the …
[PDF][PDF] B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
The long non-coding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in
female cells in early development and thereafter is thought to be largely dispensable. Here, …
female cells in early development and thereafter is thought to be largely dispensable. Here, …
[PDF][PDF] The cis-regulatory atlas of the mouse immune system
A complete chart of cis-regulatory elements and their dynamic activity is necessary to
understand the transcriptional basis of differentiation and function of an organ system. We …
understand the transcriptional basis of differentiation and function of an organ system. We …
Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing
During microbial infection, responding CD8 + T lymphocytes differentiate into heterogeneous
subsets that together provide immediate and durable protection. To elucidate the dynamic …
subsets that together provide immediate and durable protection. To elucidate the dynamic …
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
Inflammatory bowel disease (IBD) encompasses a spectrum of gastrointestinal disorders
driven by dysregulated immune responses against gut microbiota. We integrated single-cell …
driven by dysregulated immune responses against gut microbiota. We integrated single-cell …
[PDF][PDF] Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
CRISPR-Cas9 genome editing has enabled advanced T cell therapies, but occasional loss
of the targeted chromosome remains a safety concern. To investigate whether Cas9-induced …
of the targeted chromosome remains a safety concern. To investigate whether Cas9-induced …
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection
ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early
neurogenesis and in epithelial-mesenchymal transition–dependent tumor metastasis. Although the …
neurogenesis and in epithelial-mesenchymal transition–dependent tumor metastasis. Although the …
[PDF][PDF] The transcription factor Runx3 establishes chromatin accessibility of cis-regulatory landscapes that drive memory cytotoxic T lymphocyte formation
T cell receptor (TCR) stimulation of naive CD8 + T cells initiates reprogramming of cis-regulatory
landscapes that specify effector and memory cytotoxic T lymphocyte (CTL) differentiation…
landscapes that specify effector and memory cytotoxic T lymphocyte (CTL) differentiation…
Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits
T follicular helper (T FH ) cells are a distinct type of CD4 + T cells that are essential for most
antibody and B lymphocyte responses. T FH cell regulation and dysregulation is involved in …
antibody and B lymphocyte responses. T FH cell regulation and dysregulation is involved in …