Male reproductive function is key to the continuation of species and is under sophisticated
regulation, challenged by various stressors including inflammation. In the lipopolysaccharide (…

Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones
and cytokines, which are often released in a temporally varying fashion. In this study, we …

Inspired by Waddington's illustration of an epigenetic landscape, cell-fate transitions have
been envisioned as bifurcating dynamical systems, wherein exogenous signaling dynamics …

Abstract Analysis of fluctuations arising as fluorescent particles pass through a focused
laser beam has enabled quantitative characterization of a broad range of molecular kinetic …

Inspired by Waddington’s illustration of an epigenetic landscape, cell-fate transitions have
been envisioned as bifurcating dynamical systems, wherein the dynamics of an exogenous …

The study of high dimensional data sets often rely on their low dimensional projections that
preserve the local geometry of the original space. While numerous methods have been …

The circadian rhythm is an evolutionarily-conserved molecular oscillator that enables species
to anticipate rhythmic changes in their environment. At a molecular level, the core clock …

An autonomous, environmentally-synchronizable circadian rhythm is a ubiquitous feature of
life on Earth. In multicellular organisms, this rhythm is generated by a transcription--…

The increasing throughput of single-cell technologies and the pace of data generation are
enhancing the resolution at which we observe cell state transitions. The characterization and …

With the Rapid urban expansion and development, the contradiction between human and
land has gradually emerged, and how to scientifically and rationally use land is an …