INTRODUCTION The clinical manifestations of COVID-19 vary from asymptomatic infection
to respiratory failure. Severe disease courses are primarily associated with advanced age, …

FOXP3+ regulatory T cells (Tregs) maintain tolerance against self-antigens and innocuous
environmental antigens. However, it is still unknown whether Treg-mediated tolerance is …

Background Use of cell-based medicinal products (CBMPs) represents a state-of-the-art
approach for reducing general immunosuppression in organ transplantation. We tested multiple …

Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…

Regulatory macrophages (M regs) were administered to two living-donor renal transplant
recipients. Both patients were minimized to low-dose tacrolimus monotherapy within 24 wk of …

Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

In an in vitro model of cerebral ischemia (oxygen glucose deprivation, OGD) we investigated
whether erythropoietin (EPO) plays a critical role in ischemic preconditioning. We found that …

Identifying transplant recipients in whom immunological tolerance is established or is developing
would allow an individually tailored approach to their posttransplantation management. …

Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection rates and a substantially lower risk for developing severe coronavirus disease 2019 …

Objective To assess whether reshaping of the immune balance by infusion of autologous
natural regulatory T cells (nTregs) in patients after kidney transplantation is safe, feasible, and …