Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alzheimer’s disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

The energy landscape of the monomer and dimer are explored for the amyloidogenic
heptapeptide GNNQQNY from the N-terminal prion-determining domain of the yeast protein Sup35…

This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is sensitive …

Intrinsically disordered proteins are essential for biological processes such as cell signalling,
but are also associated to devastating diseases including Alzheimer's disease, Parkinson's …

One of the main research topics related to Alzheimer’s disease is the aggregation of the
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms of …

In amyloid aggregation diseases soluble proteins coalesce into a wide array of undesirable
structures, ranging through oligomers and prefibrillar assemblies to highly ordered amyloid …

Thermophilic polyester hydrolases (PES-H) have recently enabled biocatalytic recycling of
the mass-produced synthetic polyester polyethylene terephthalate (PET), which has found …

We model oligomers of the Alzheimer’s amyloid β-peptide Aβ 1−42 in an implicit membrane
to obtain insight into the mechanism of amyloid toxicity. It has been suggested that Aβ …