User profiles for Bishnu P Paudel
 | Bishnu PaudelResearch Fellow Verified email at uow.edu.au Cited by 420 |
Molecular crowding accelerates ribozyme docking and catalysis
All biological processes take place in highly crowded cellular environments. However, the
effect that molecular crowding agents have on the folding and catalytic properties of RNA …
effect that molecular crowding agents have on the folding and catalytic properties of RNA …
A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
Telomeric G-quadruplexes (G4) were long believed to form a protective structure at telomeres,
preventing their extension by the ribonucleoprotein telomerase. Contrary to this belief, we …
preventing their extension by the ribonucleoprotein telomerase. Contrary to this belief, we …
Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response
10.7554/eLife.42761.001 The RecA protein orchestrates the cellular response to DNA
damage via its multiple roles in the bacterial SOS response. Lack of tools that provide …
damage via its multiple roles in the bacterial SOS response. Lack of tools that provide …
Real-time single-molecule observation of chaperone-assisted protein folding
The ability of heat shock protein 70 (Hsp70) molecular chaperones to remodel the conformation
of their clients is central to their biological function; however, questions remain regarding …
of their clients is central to their biological function; however, questions remain regarding …
Optimal molecular crowding accelerates group II intron folding and maximizes catalysis
Unlike in vivo conditions, group II intron ribozymes are known to require high magnesium(II)
concentrations ([Mg 2+ ]) and high temperatures (42 C) for folding and catalysis in vitro. A …
concentrations ([Mg 2+ ]) and high temperatures (42 C) for folding and catalysis in vitro. A …
An α-cyanostilbene derivative for the enhanced detection and imaging of amyloid fibril aggregates
…, KM Wray, CL Johnston, BP Paudel… - ACS Chemical …, 2020 - ACS Publications
The aggregation of proteins into amyloid fibrils has been implicated in the pathogenesis of a
variety of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s …
variety of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s …
Recruitment, duplex unwinding and protein-mediated inhibition of the dead-box RNA helicase Dbp2 at actively transcribed chromatin
RNA helicases play fundamental roles in modulating RNA structures and facilitating RNA–protein
(RNP) complex assembly in vivo. Previously, our laboratory demonstrated that the …
(RNP) complex assembly in vivo. Previously, our laboratory demonstrated that the …
[HTML][HTML] CHD4 slides nucleosomes by decoupling entry-and exit-side DNA translocation
Chromatin remodellers hydrolyse ATP to move nucleosomal DNA against histone octamers.
The mechanism, however, is only partially resolved, and it is unclear if it is conserved …
The mechanism, however, is only partially resolved, and it is unclear if it is conserved …
[HTML][HTML] Single-molecule fluorescence-based approach reveals novel mechanistic insights into human small heat shock protein chaperone function
CL Johnston, NR Marzano, BP Paudel, G Wright… - Journal of Biological …, 2021 - ASBMB
Small heat shock proteins (sHsps) are a family of ubiquitous intracellular molecular chaperones;
some sHsp family members are upregulated under stress conditions and play a vital …
some sHsp family members are upregulated under stress conditions and play a vital …
[HTML][HTML] The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families
CHD4 is an essential, widely conserved ATP-dependent translocase that is also a broad
tumour dependency. In common with other SF2-family chromatin remodelling enzymes, it alters …
tumour dependency. In common with other SF2-family chromatin remodelling enzymes, it alters …