Increased fracture risk represents an emerging and severe complication of diabetes. The
resulting prolonged immobility and hospitalisations can lead to substantial morbidity and …

Aging decreases the human femur’s fatigue resistance, impact energy absorption, and the
ability to withstand load. Changes in the osteocyte distribution and in their elemental …

The differentiation and degree of the effects of mineral content and/or morphology on bone
quality remain, to a large extent, unanswered due to several microarchitectural particularities …

Aging and bone diseases are associated with increased fracture risk. It is therefore pertinent
to seek an understanding of the origins of such disease-related deterioration in bone's …

Osteocytes are ramified bone cells distributed throughout the bone matrix within a network
of micrometer-scale cavities (lacunae) and numerous nanometer-thick tunnels (canaliculi). …

Osteoclasts are unique cells capable of bone resorption and therefore have become a major
target in osteoporosis treatment strategies. Bisphosphonates suppress bone turnover via …

Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass
and microarchitectural deterioration. Here, we show that warmth exposure (34C) protects …

Inflammation has important roles in tissue regeneration, autoimmunity, and cancer. Different
inflammatory stimuli can lead to bone loss by mechanisms that are not well understood. We …

Vitamin D deficiency is a widespread medical condition that plays a major role in human
bone health. Fracture susceptibility in the context of low vitamin D has been primarily …

Bisphosphonates are the most widely prescribed pharmacologic treatment for osteoporosis
and reduce fracture risk in postmenopausal women by up to 50%. However, in the past …