The life cycles of many parasites involve transitions between disparate host species, requiring
these parasites to go through multiple developmental stages adapted to each of these …

The application of metabolomics, the global analysis of metabolite levels, to the study of
protozoan parasites has become an important tool for understanding the host-parasite …

Perforin-like proteins are expressed by many bacterial and protozoan pathogens, yet little is
known about their function or mode of action. Here, we describe Toxoplasma perforin-like …

The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic
persistence in human red blood cells, continuously evading host immunity using …

Pathogens have to balance transmission with persistence. For Plasmodium falciparum, the
most widespread and virulent malaria parasite, persistence within its human host requires …

… We would like to thank Jessica King, Kirk Deitsch, and members of the Kafsack Lab for
careful reading and thoughtful feedback. This work was supported by funding to BK from …

For Plasmodium falciparum, the most widespread and virulent malaria parasite that infects
humans, persistence depends on continuous asexual replication in red blood cells, while …

Human to vector transmission of malaria requires that some blood-stage parasites abandon
asexual growth and convert into non-replicating sexual forms called gametocytes. The initial …

Host cell invasion is an essential step during infection by Toxoplasma gondii, an intracellular
protozoan that causes the severe opportunistic disease toxoplasmosis in humans. Recent …

Numerous perforin-like proteins are encoded in the genomes of apicomplexan parasites,
where they are expressed in various life-cycle stages and play critical roles pathogenesis and …