Bacterial NusG is a highly conserved transcription factor that is required for most Rho activity
in vivo. We show by nuclear magnetic resonance spectroscopy that Escherichia coli NusG …

Neurodegeneration in patients with Parkinson’s disease is correlated with the occurrence of
Lewy bodies—intracellular inclusions that contain aggregates of the intrinsically disordered …

NusG homologs regulate transcription and coupled processes in all living organisms. The
Escherichia coli (E. coli) two-domain paralogs NusG and RfaH have conformationally identical …

The biogenesis of integral outer-membrane proteins (OMPs) in Gram-negative bacteria
requires molecular chaperones that prevent the aggregation of OMP polypeptides in the …

Chaperones increase the folding yields of soluble proteins by suppressing misfolding and
aggregation, but how they modulate the folding of integral membrane proteins is not well …

TamA is an Escherichia coli Omp85 protein involved in autotransporter biogenesis. It comprises
a 16-stranded transmembrane β-barrel and three POTRA domains. The 2.3-Å crystal …

Mutations in glucocerebrosidase (GBA) are the most prevalent genetic risk factor for Lewy
body disorders (LBD)—collectively Parkinson’s disease, Parkinson’s disease dementia and …

Disulfide bond formation is fundamentally important for protein structure and constitutes a
key mechanism by which cells regulate the intracellular oxidation state. Peroxiredoxins (…

The chaperone Trigger Factor (TF) from Escherichia coli forms a dimer at cellular
concentrations. While the monomer structure of TF is well known, the spatial arrangement of this …

Peroxiredoxins (PRDXs) are abundant peroxidases present in all kingdoms of life. Recently,
they have been shown to also carry out additional roles as molecular chaperones. To …