Interleukin-6 (IL-6) activates cells by binding to the membrane-bound IL-6 receptor (IL-6R)
and subsequent formation of a glycoprotein 130 homodimer. Cells that express glycoprotein …

Human exploration of the Moon is associated with substantial risks to astronauts from space
radiation. On the surface of the Moon, this consists of the chronic exposure to galactic …

Human ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine that exerts a neuroprotective
effect in multiple sclerosis and amyotrophic lateral sclerosis. Clinical application of …

Background ADNP is essential for embryonic development. As such, de novo ADNP
mutations lead to an intractable autism/intellectual disability syndrome requiring investigation. …

It is established that cytokine receptors signal after ligand binding as homo- or hetero-dimers
in heteromeric complexes, but it is unclear, when dimerization occurs. To investigate gp130 …

Soluble gp130 is the natural inhibitor of trans-signaling mediated by the soluble IL-6/IL-6R
complex. In mouse models, recombinant sgp130 has been successfully applied for the …

Chang’E 4 is the first mission to the far side of the Moon and consists of a lander, a rover,
and a relay spacecraft. Lander and rover were launched at 18:23 UTC on December 7, 2018 …

Lysosome-associated membrane glycoprotein 3 (LAMP3) is a type I transmembrane protein
of the LAMP protein family with a cell-type-specific expression in alveolar type II cells in …

The recently solved X-ray structure of the extracellular portion of the interleukin-6 (IL-6)
receptor (IL-6R) revealed an IL-6R dimer in the crystal lattice which probably represents a …

In mammals, the ORMDL family of evolutionarily conserved sphingolipid regulators consists
of three highly homologous members, ORMDL1, ORMDL2 and ORMDL3. ORMDL3 gene …