Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular
heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights …

Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic tumor …

Background & Aims Countries endemic for parasitic infestations have a lower incidence of
Crohn’s disease (CD) than nonendemic countries, and there have been anecdotal reports of …

We describe a multipurpose technology platform, termed μSCALE (microcapillary single-cell
analysis and laser extraction), that enables massively parallel, quantitative biochemical and …

Background & Aims Acinar to ductal metaplasia (ADM) occurs in the pancreas in response
to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies …

Patellofemoral pain syndrome (PFPS) is a common knee problem with a diverse aetiology.
One of the clinically well accepted risk factors is malalignment of the lower extremities, …

Background Mobile-gaming athletes sit in the same posture for prolonged periods, contributing
to significant health risks. This study investigated the health profiles, fatigue, pain and …

DNA methylation of enhancers is dynamic, cell-type specific, and vital for cell fate progression.
However, current models inadequately define its role within the hierarchy of gene …

Simple Summary Professional mobile esports athletes may suffer from occupational health
risks to their spine because of prolonged sitting with poor posture. The aim of this study is to …

The role of intratumor heterogeneity is becoming increasingly apparent in part due to expansion
in single cell technologies. Clinically, tumor heterogeneity poses several obstacles to …