Study of the nematode Caenorhabditis elegans has provided important insights in a wide
range of fields in biology. The ability to precisely modify genomes is critical to fully realize the …

The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …

A central goal in the development of genome engineering technology is to reduce the time
and labor required to produce custom genome modifications. Here we describe a new …

Biologists have long recognized that dramatic bending of a cell sheet may be driven by even
modest shrinking of the apical sides of cells. Cell shape changes and tissue movements …

Apical constriction is a cell shape change that promotes tissue remodeling in a variety of
homeostatic and developmental contexts, including gastrulation in many organisms and neural …

Anteroposterior asymmetries are apparent in C. elegans development before the first cell
division. Here we identify the cue that specifies the anteroposterior axis, and investigate how …

Optical imaging of the dynamics of living specimens involves tradeoffs between spatial
resolution, temporal resolution, and phototoxicity, made more difficult in three dimensions. Here, …

The advent of genome editing techniques based on the clustered regularly interspersed short
palindromic repeats (CRISPR)–Cas9 system has revolutionized research in the biological …

Tardigrades are microscopic animals that survive a remarkable array of stresses, including
desiccation. How tardigrades survive desiccation has remained a mystery for more than 250 …

Apical constriction changes cell shapes, driving critical morphogenetic events, including
gastrulation in diverse organisms and neural tube closure in vertebrates. Apical constriction is …