[HTML][HTML] Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

…, CL Worth, C Schweiger, S Liebs, M Lange… - Nature …, 2017 - nature.com
Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours
responding to available therapies, requiring a better molecular understanding of the disease …

[PDF][PDF] Asterless is a centriolar protein required for centrosome function and embryo development in Drosophila

H Varmark, S Llamazares, E Rebollo, B Lange, J Reina… - Current Biology, 2007 - cell.com
Background Centrosomes, the major organizers of the microtubule network in most animal
cells, are composed of centrioles embedded in a web of pericentriolar material (PCM). …

[PDF][PDF] Efficient parameter estimation enables the prediction of drug response using a mechanistic pan-cancer pathway model

…, M Heinig, FJ Theis, H Lehrach, C Wierling, B Lange… - Cell systems, 2018 - cell.com
Mechanistic models are essential to deepen the understanding of complex diseases at the
molecular level. Nowadays, high-throughput molecular and phenotypic characterizations are …

Proteomic and functional analysis of the mitotic Drosophila centrosome

…, J Gobom, A Ploubidou, M Boutros, BMH Lange - The EMBO …, 2010 - embopress.org
Regulation of centrosome structure, duplication and segregation is integrated into cellular
pathways that control cell cycle progression and growth. As part of these pathways, numerous …

Development of an oral vaccine for immunisation of rainbow trout (Oncorhynchus mykiss) against viral haemorrhagic septicaemia

…, B Köllner, SM Bergmann, U Fischer, B Lange… - Vaccine, 2008 - Elsevier
In the European Union Viral Haemorrhagic Septicaemia (VHS) eradication is still based on
stamping out. Due to the lack of effective low cost vaccines immune prophylaxis is currently …

[HTML][HTML] Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates

BMH Lange, A Bachi, M Wilm, C González - The EMBO journal, 2000 - embopress.org
To determine the molecular composition of the centrosome of a higher eukaryote, we carried
out a systematic nano-electrospray tandem or MALDI mass spectrometry analysis of the …

[HTML][HTML] LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells

…, H Lehrach, J Gobom, E Nordhoff, BMH Lange - Nature …, 2013 - nature.com
Centrosome morphology and number are frequently deregulated in cancer cells. Here, to
identify factors that are functionally relevant for centrosome abnormalities in cancer cells, we …

[HTML][HTML] A framework for validating AI in precision medicine: considerations from the European ITFoC consortium

…, S Coman, O Hijano Cubelos, A Itu, B Lange… - BMC medical informatics …, 2021 - Springer
Background Artificial intelligence (AI) has the potential to transform our healthcare systems
significantly. New AI technologies based on machine learning approaches should play a key …

Oral immunisation against classical swine fever (CSF): onset and duration of immunity

V Kaden, B Lange - Veterinary microbiology, 2001 - Elsevier
In an experimental study, onset and duration of immunity after oral immunisation of pigs with
a classical swine fever (CSF) live virus vaccine based on the strain “C” has been evaluated. …

The micromechanical behavior of implant‐abutment connections under a dynamic load protocol

H Zipprich, P Weigl, C Ratka, B Lange… - … implant dentistry and …, 2018 - Wiley Online Library
Background The implant‐abutment connection (IAC) is known to be a key factor for the long‐term
stability of peri‐implant tissue. Purpose The aim of the present in vitro study was to …