User profiles for Bodo Laube
 | Bodo LaubeVerified email at bio.tu-darmstadt.de Cited by 10052 |
Evidence for a tetrameric structure of recombinant NMDA receptors
The amino acids l-glutamate and glycine are essential agonists of the excitatory NMDA
receptor, a subtype of the ionotropic glutamate receptor family. The native NMDA receptor is …
receptor, a subtype of the ionotropic glutamate receptor family. The native NMDA receptor is …
[PDF][PDF] Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit
NMDA receptors require both L-glutamate and the coagonist glycine for efficient channel
activation. The glycine binding site of these heteromeric receptor proteins is formed by regions …
activation. The glycine binding site of these heteromeric receptor proteins is formed by regions …
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes
…, N Villeneuve, L Villard, B Zabel, M Zenker, B Laube… - Nature …, 2010 - nature.com
N-methyl-D-aspartate (NMDA) receptors mediate excitatory neurotransmission in the
mammalian brain. Two glycine-binding NR1 subunits and two glutamate-binding NR2 subunits …
mammalian brain. Two glycine-binding NR1 subunits and two glutamate-binding NR2 subunits …
Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes
…, I Steiner, M Nothnagel, M Alber, K Geider, B Laube… - Nature …, 2013 - nature.com
Idiopathic focal epilepsy (IFE) with rolandic spikes is the most common childhood epilepsy,
comprising a phenotypic spectrum from rolandic epilepsy (also benign epilepsy with …
comprising a phenotypic spectrum from rolandic epilepsy (also benign epilepsy with …
Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins
Activation of the NMDA subtype of ionotropic glutamate receptors requires binding of both L-glutamate
and the coagonist glycine. Site-directed mutagenesis of the NMDARI (NRl) …
and the coagonist glycine. Site-directed mutagenesis of the NMDARI (NRl) …
Loss of postsynaptic GABAA receptor clustering in gephyrin-deficient mice
M Kneussel, JH Brandstätter, B Laube… - Journal of …, 1999 - Soc Neuroscience
The tubulin-binding protein gephyrin, which anchors the inhibitory glycine receptor (GlyR) at
postsynaptic sites, decorates GABAergic postsynaptic membranes in various brain regions, …
postsynaptic sites, decorates GABAergic postsynaptic membranes in various brain regions, …
[HTML][HTML] The β subunit determines the ligand binding properties of synaptic glycine receptors
…, S Haeger, A Nicke, G Schmalzing, H Betz, B Laube - Neuron, 2005 - cell.com
Inhibitory glycine receptors (GlyRs) regulate motor coordination and sensory signal
processing in spinal cord and other brain regions. GlyRs are pentameric proteins composed of …
processing in spinal cord and other brain regions. GlyRs are pentameric proteins composed of …
Glycine receptors: recent insights into their structural organization and functional diversity
H Betz, B Laube - Journal of neurochemistry, 2006 - Wiley Online Library
Strychnine‐sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in
spinal cord, brainstem and other regions of the CNS. During the past 5 years, considerable …
spinal cord, brainstem and other regions of the CNS. During the past 5 years, considerable …
[PDF][PDF] Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality
…, W Armsen, V Eulenburg, DW Richter, B Laube… - Neuron, 2003 - cell.com
The glycine transporter subtype 2 (GlyT2) is localized in the axon terminals of glycinergic
neurons. Mice deficient in GlyT2 are normal at birth but during the second postnatal week …
neurons. Mice deficient in GlyT2 are normal at birth but during the second postnatal week …
GRIN2B mutations in west syndrome and intellectual disability with focal epilepsy
Objective To identify novel epilepsy genes using a panel approach and describe the functional
consequences of mutations. Methods Using a panel approach, we screened 357 patients …
consequences of mutations. Methods Using a panel approach, we screened 357 patients …