User profiles for Bogdan Tanasa

Bogdan Tanasa, MD PhD

Stanford University
Verified email at stanford.edu
Cited by 8654

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

…, M Prakriya, S Srikanth, SH Puppel, B Tanasa… - Nature, 2006 - nature.com
Antigen stimulation of immune cells triggers Ca 2+ entry through Ca 2+ release-activated
Ca 2+ (CRAC) channels, promoting the immune response to pathogens by activating the …

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

W Li, D Notani, Q Ma, B Tanasa, E Nunez, AY Chen… - Nature, 2013 - nature.com
The functional importance of gene enhancers in regulated gene expression is well established
1 , 2 , 3 . In addition to widespread transcription of long non-coding RNAs (lncRNAs) in …

REGULATION OF TH2 DIFFERENTIATION AND Il4 LOCUS ACCESSIBILITY

KM Ansel, I Djuretic, B Tanasa, A Rao - Annu. Rev. Immunol., 2006 - annualreviews.org
Helper T cells coordinate immune responses through the production of cytokines. Th2 cells
express the closely linked Il4, Il13, and Il5 cytokine genes, whereas these same genes are …

lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs

L Yang, C Lin, C Jin, JC Yang, B Tanasa, W Li… - Nature, 2013 - nature.com
Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in
physiological aspects of cell-type determination and tissue homeostasis 1 , their potential …

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

O Harismendy, D Notani, X Song, NG Rahim, B Tanasa… - Nature, 2011 - nature.com
Genome-wide association studies have identified single nucleotide polymorphisms (SNPs)
in the 9p21 gene desert associated with coronary artery disease (CAD) 1 , 2 , 3 , 4 and type 2 …

[HTML][HTML] Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer

C Lin, L Yang, B Tanasa, K Hutt, B Ju, KA Ohgi… - Cell, 2009 - cell.com
Chromosomal translocations are a hallmark of leukemia/lymphoma and also appear in solid
tumors, but the underlying mechanism remains elusive. By establishing a cellular model …

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

Y Gwack, S Sharma, J Nardone, B Tanasa, A Iuga… - Nature, 2006 - nature.com
Precise regulation of the NFAT (nuclear factor of activated T cells) family of transcription factors
(NFAT1–4) is essential for vertebrate development and function 1 . In resting cells, NFAT …

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

W Liu, B Tanasa, OV Tyurina, TY Zhou, R Gassmann… - Nature, 2010 - nature.com
While reversible histone modifications are linked to an ever-expanding range of biological
functions 1 , 2 , 3 , 4 , 5 , the demethylases for histone H4 lysine 20 and their potential …

Genome-informed targeted therapy for osteosarcoma

…, AG Lee, HY Liu, A Spillinger, AT Shah, B Tanasa… - Cancer discovery, 2019 - AACR
Osteosarcoma is treated with a chemotherapy regimen established 30 years ago. Although
osteosarcoma is genomically complex, we hypothesized that tumor-specific dependencies …

[PDF][PDF] Condensin I and II complexes license full estrogen receptor α-dependent enhancer activation

…, Q Ma, D Merkurjev, X Song, X Zhou, Z Liu, B Tanasa… - Molecular cell, 2015 - cell.com
Enhancers instruct spatio-temporally specific gene expression in a manner tightly linked to
higher-order chromatin architecture. Critical chromatin architectural regulators condensin I …