Functional magnetic resonance imaging (fMRI) was used to investigate the changes in
blood oxygenation level dependent (BOLD) signal, cerebral blood flow (CBF) and cerebral …

The spatiotemporal evolution of cerebral microcirculatory adjustments to functional brain
stimulation is the fundamental determinant of the functional specificity of hemodynamically …

The majority of patients with Alzheimer’s disease have cerebral amyloid angiopathy, thus
showing deposition of amyloid-β peptides in the walls of leptomeningeal and cortical arterioles…

Blood-brain barrier (BBB) disruption can be achieved with ultrasound (US) and circulating
microbubble (MB) contrast agent. Using dorsal US sonication and Definity, an MB contrast …

Reversible and localized blood–brain barrier disruption (BBBD) using focused ultrasound (FUS)
in combination with intravascularly administered microbubbles (MBs) has been …

Objective: To examine the clinical and biomarker characteristics of patients with amyloid-negative
Alzheimer disease (AD) and mild cognitive impairment (MCI) from the Alzheimer's …

Objective: To assess the frequency and phenotype of hexanucleotide repeat expansions in
C9ORF72 in a large cohort of patients of Dutch descent with familial (fALS) and sporadic (…

Many promising findings from pre-clinical research have failed to translate to the clinic due
to their inability to incorporate human disease co-morbidity. A variety of rodent diets and …

The spatial and temporal response of the cerebral microcirculation to mild hypercapnia was
investigated via two-photon laser-scanning microscopy. Cortical vessels, traversing the top …

The specificity of the hemodynamic response function (HRF) is determined spatially by the
vascular architecture and temporally by the evolution of hemodynamic changes. The stimulus …