The genetic architecture of type 2 diabetes
The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…
[HTML][HTML] JNK-and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 …
Mitochondrial translocation of pro-apoptotic Bax prior to apoptosis is well established after
treatment with many cell death stimulants or under apoptosis-inducing conditions. The …
treatment with many cell death stimulants or under apoptosis-inducing conditions. The …
[HTML][HTML] The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery
The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …
catalog of high-resolution reference epigenomes of major primary human cell types. The …
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
…, T Jørgensen, A Käräjämäki, BJ Kim, SS Kim… - Nature …, 2018 - nature.com
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D) 1 , 2 ; however, most of these loci have …
loci that are associated with type 2 diabetes (T2D) 1 , 2 ; however, most of these loci have …
[HTML][HTML] Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with …
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with …
A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea
…, MH Kim, MD Kim, BJ Kim, SK Kim… - Journal of …, 2011 - content.iospress.com
We investigated the prevalence of dementia and mild cognitive impairment (MCI) and the
factors associate with risk of dementia from a representative nationwide sample of Korean …
factors associate with risk of dementia from a representative nationwide sample of Korean …
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Recent genetic association studies have identified 55 genetic loci associated with obesity or
body mass index (BMI). The vast majority, 51 loci, however, were identified in European-…
body mass index (BMI). The vast majority, 51 loci, however, were identified in European-…
[HTML][HTML] The Korea Biobank Array: design and identification of coding variants associated with blood biochemical traits
…, YK Kim, TJ Park, DS Song, JK Park, JE Lee, BJ Kim - Scientific reports, 2019 - nature.com
We introduce the design and implementation of a new array, the Korea Biobank Array (referred
to as KoreanChip), optimized for the Korean population and demonstrate findings from …
to as KoreanChip), optimized for the Korean population and demonstrate findings from …