Metabolic complications in an obese state can be aggravated by an abnormal inflammatory
response and enhanced production of reactive oxygen species. Pro-inflammatory response …

Oxidative stress and inflammation remain the major complications implicated in the development
and progression of metabolic complications, including obesity, type 2 diabetes (T2D) …

… inflammation by reducing the levels of pro-inflammatory markers such as tumor necrosis
factor-α, interleukin (IL)-6, cyclooxygenase-2, IL-1β, as well as blocking nuclear factor kappa B (…

Oxidative stress is a key pathological feature implicated in both acute and chronic liver diseases,
including drug-induced liver injury (DILI). The latter describes hepatic injury arising as a …

Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the detrimental …

Diabetic neuropathy is a risk factor for developing complications such as autonomic cardiovascular
disease, osteoarthropathy, foot ulcers, and infections, which may be the direct cause …

Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure,
has been extensively studied as a potential avenue to combat obesity. Although BAT is …

Brown adipose tissue (BAT) is increasingly recognized as the major therapeutic target to
promote energy expenditure and ameliorate diverse metabolic complications. There is a …

The T-helper (Th1/Th2) paradigm is widely studied for its role in modulating an adaptive
immune response, especially in relation to the onset of various autoimmune diseases. In fact, …

Background: The use of oral contraceptives (OCs) is associated with an increased risk of
cardiovascular events such as arterial and venous thrombosis (VTE). Cardiovascular diseases (…