Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic
transmission throughout the central nervous system. Accordingly, eCBs are involved in neural …

Objective: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces
opioid system activation. The objective of this study was to determine whether opioid receptor …

Endocannabinoids (eCBs) have emerged as key activity-dependent signals that, by activating
presynaptic cannabinoid receptors (ie, CB1) coupled to G i/o protein, can mediate short-…

Several symptoms associated with chronic pain, including fatigue and depression, are
characterized by reduced motivation to initiate or complete goal-directed tasks. However, it is …

Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and disorders…

Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder.
However, the neural mechanisms that underlie sociability are poorly understood, limiting the …

Social isolation during opioid withdrawal is a major contributor to the current opioid addiction
crisis. We find that sociability deficits during protracted opioid withdrawal in mice require …

Social memory—the ability to recognize and remember familiar conspecifics—is critical for
the survival of an animal in its social group 1 , 2 . The dorsal CA2 (dCA2) 3 , 4 – 5 and ventral …

We recently reported that naltrexone blocks antidepressant effects of ketamine in humans,
indicating that antidepressant effects of ketamine require opioid receptor activation. However, …

The central amygdala (CeA) orchestrates adaptive responses to emotional events. While
CeA substrates for defensive behaviors have been studied extensively, CeA circuits for …