The intricate geometry of cytoskeletal networks and internal membranes causes the space
available for diffusion in cytoplasm to be convoluted, thereby affecting macromolecule …

Cell biological processes are controlled by an interacting set of biochemical and electrophysiological
events that are distributed within complex cellular structures. Computational models…

An algorithm is presented for solving a diffusion equation on a curved surface coupled to
diffusion in the volume, a problem often arising in cell biology. It applies to pixilated surfaces …

The Virtual Cell (VCell) is a general computational framework for modeling physicochemical
and electrophysiological processes in living cells. Developed by the National Resource for …

Hybrid deterministic-stochastic methods provide an efficient alternative to a fully stochastic
treatment of models which include components with disparate levels of stochasticity. However…

The Virtual Cell (VCell; http://vcell.org/) is a problem solving environment, built on a central
database, for analysis, modelling and simulation of cell biological processes. VCell integrates …

The separate components of nucleocytoplasmic transport have been well characterized,
including the key regulatory role of Ran, a guanine nucleotide triphosphatase. However, the …

The shape of a cell, the sizes of subcellular compartments, and the spatial distribution of
molecules within the cytoplasm can all control how molecules interact to produce a cellular …

▪ Abstract The field of computational cell biology has emerged within the past 5 years
because of the need to apply disciplined computational approaches to build and test complex …

In living cells, the cytoskeleton connects to the extracellular environment through focal
adhesions, multimolecular structures that can sense applied force. A model is presented that for …