The specificity of cellular responses to receptor stimulation is encoded by the spatial and
temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to …

… Hoek, Boris N. Kholodenko; Signaling switches and bistability arising from multisite
phosphorylation in protein kinase cascades . J Cell Biol 2 February 2004; 164 (3): 353–359. doi: https…

Functional organization of signal transduction into protein phosphorylation cascades, such
as the mitogen‐activated protein kinase (MAPK) cascades, greatly enhances the sensitivity of …

During the past decade, our knowledge of molecular mechanisms involved in growth factor
signaling has proliferated almost explosively. However, the kinetics and control of …

Although we have amassed extensive catalogues of signalling network components, our
understanding of the spatiotemporal control of emergent network structures has lagged behind. …

In the present paper, we describe multiple levels of cross-talk between the PI3K (phosphoinositide
3-kinase)/Akt and Ras/MAPK (mitogen-activated protein kinase) signalling pathways. …

Emerging technologies have enabled the acquisition of large genomics and proteomics data
sets. However, current methodologies for analysis do not permit interpretation of the data in …

Cancer is often considered a genetic disease. However, much of the enormous plasticity of
cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and …

Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers.
To help understand ErbB signaling quantitatively, in this work we combine traditional …

Crosstalk mechanisms have not been studied as thoroughly as individual signaling pathways.
We exploit experimental and computational approaches to reveal how a concordant …