User profiles for Boxi Kang

Boxi Kang

Peking University
Verified email at pku.edu.cn
Cited by 14876

[HTML][HTML] Understanding tumor ecosystems by single-cell sequencing: promises and limitations

X Ren, B Kang, Z Zhang - Genome biology, 2018 - Springer
Cellular heterogeneity within and across tumors has been a major obstacle in understanding
and treating cancer, and the complex heterogeneity is masked if bulk tumor tissues are …

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Z Tang, C Li, B Kang, G Gao, C Li… - Nucleic acids …, 2017 - academic.oup.com
Tremendous amount of RNA sequencing data have been produced by large consortium
projects such as TCGA and GTEx, creating new opportunities for data mining and deeper …

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

Z Tang, B Kang, C Li, T Chen, Z Zhang - Nucleic acids research, 2019 - academic.oup.com
Introduced in 2017, the GEPIA (Gene Expression Profiling Interactive Analysis) web server
has been a valuable and highly cited resource for gene expression analysis based on tumor …

[PDF][PDF] Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing

…, L Zheng, JK Yoo, H Guo, Y Zhang, X Guo, B Kang… - Cell, 2017 - cell.com
Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of
immunotherapies and the prediction of their clinical responses in cancers. Here, we perform deep …

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

…, L Zheng, C Zheng, J Song, Q Zhang, B Kang… - Nature medicine, 2018 - nature.com
Cancer immunotherapies have shown sustained clinical responses in treating non-small-cell
lung cancer 1 , 2 – 3 , but efficacy varies and depends in part on the amount and properties …

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

…, X Yu, L Zheng, Y Zhang, Y Li, Q Fang, R Gao, B Kang… - Nature, 2018 - nature.com
T cells are key elements of cancer immunotherapy 1 but certain fundamental properties,
such as the development and migration of T cells within tumours, remain unknown. The …

Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity

…, G Schlecht-Louf, R Krzysiek, L Zitvogel, B Kang… - Nature medicine, 2019 - nature.com
Psychological distress has long been suspected to influence cancer incidence and mortality.
It remains largely unknown whether and how stress affects the efficacy of anticancer …

[HTML][HTML] SciBet as a portable and fast single cell type identifier

C Li, B Liu, B Kang, Z Liu, Y Liu, C Chen, X Ren… - Nature …, 2020 - nature.com
Fast, robust and technology-independent computational methods are needed for supervised
cell type annotation of single-cell RNA sequencing data. We present SciBet, a supervised …

[HTML][HTML] Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis

R Yang, S Cheng, N Luo, R Gao, K Yu, B Kang… - Genome biology, 2020 - Springer
Background Tumor-reactive CD8+ tumor-infiltrating lymphocytes (TILs) represent a subtype
of T cells that can recognize and destroy tumor specifically. Understanding the regulatory …

[HTML][HTML] Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune …

…, Z He, A Cui, Y Zhou, J Wu, M Zhou, G Yuan, B Kang… - Cell Discovery, 2022 - nature.com
SARS-CoV-2 vaccine booster dose can induce a robust humoral immune response, however,
its cellular mechanisms remain elusive. Here, we investigated the durability of antibody …