The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …

The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle
East respiratory syndrome (MERS)-CoV underscores the threat of cross-species …

Coronaviruses are prone to transmission to new host species, as recently demonstrated by
the spread to humans of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the novel viral disease COVID-19. With no approved therapies, this pandemic illustrates the …

Outbreaks from zoonotic sources represent a threat to both human disease as well as the
global economy. Despite a wealth of metagenomics studies, methods to leverage these …

Severe acute respiratory syndrome with high mortality rates (∼50%) is associated with a
novel group 2c betacoronavirus designated Middle East respiratory syndrome coronavirus (…

A novel human coronavirus (HCoV-EMC) was recently identified in the Middle East as the
causative agent of a severe acute respiratory syndrome (SARS) resembling the illness caused …

The sudden emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in
2002 and, more recently, Middle Eastern respiratory syndrome CoV (MERS-CoV) …

Progress toward understanding Zika virus (ZIKV) pathogenesis is hindered by lack of
immunocompetent small animal models, in part because ZIKV fails to effectively antagonize Stat2-…

Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that emerged in
2012, causing acute respiratory distress syndrome (ARDS), severe pneumonia-like …