Many studies have highlighted the role that microRNAs have in physiological processes
and how their deregulation can lead to cancer. More recently, it has been proposed that the …

Survivin is one of the most cancer-specific proteins identified to date, being upregulated in
almost all human tumors. Biologically, survivin has been shown to inhibit apoptosis, enhance …

Survivin is a 16.5kDa protein overexpressed in almost all malignancies but rarely detected
in normal differentiated adult tissues. Functionally, survivin has been shown to inhibit …

Background Lung cancer is the leading cancer diagnosis worldwide and the number one
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer, …

SOMAscan is an aptamer-based proteomics assay capable of measuring 1,305 human
protein analytes in serum, plasma, and other biological matrices with high sensitivity and …

The ADAMs are a family of membrane proteins possessing a disintegrin and metalloprotease
domain. One of their main functions is shedding of membrane proteins. The aim of this …

Normal tissue homeostasis is maintained through asymmetric cell divisions that produce
daughter cells with differing self-renewal and differentiation potentials. Certain tumor cell …

Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is classically
characterized according to its role in the central nervous system as a neurotransmitter. In …

Compared with all other racial and ethnic groups in the United States, African Americans are
disproportionally affected by lung cancer, both in terms of incidence and survival. It is likely …

Purpose: To determine whether racial differences in gene and miRNA expression translates
to differences in lung tumor biology with clinical relevance in African Americans (AAs) and …