Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum
of their possible activation states is not well understood. We derived co-regulated gene …

Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in
amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar degeneration (FTLD-…

Synapse loss and Tau pathology are hallmarks of Alzheimer's disease (AD) and other
tauopathies, but how Tau pathology causes synapse loss is unclear. We used unbiased proteomic …

A common approach to understanding neurodegenerative disease is comparing gene
expression in diseased versus healthy tissues. We illustrate that expression profiles derived from …

Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2
deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a …

Oligodendrocyte dysfunction has been implicated in the pathogenesis of neurodegenerative
diseases, so understanding oligodendrocyte activation states would shed light on disease …

Damage-associated microglia (DAM) profiles observed in Alzheimer's disease (AD)-related
mouse models reflect an activation state that could modulate AD risk or progression. To …

Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

A propensity for rewiring genetic and epigenetic regulatory networks, thus enabling sustained
cell proliferation, suppression of apoptosis, and the ability to evade the immune system, is …

Advances in human genetics have implicated a growing number of genes in neurodegenerative
diseases, providing insight into pathological processes. For Alzheimer disease in …