Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia.
Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

In 265 Irish pedigrees, with linkage analysis we find evidence for a vulnerability locus for
schizophrenia in region 6p24–22. The greatest lod score, assuming locus heterogeneity, is …

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

Many common illnesses, for reasons that have not been identified, differentially affect men
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …

The assumption that the transmission of social behaviors and political preferences is purely
cultural has been challenged repeatedly over the last 40 years by the combined evidence of …

Prestin, a membrane protein that is highly and almost exclusively expressed in the outer
hair cells (OHCs) of the cochlea, is a motor protein which senses membrane potential and …