FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy
…, JE Mannix, TF Mao, BW Carney… - American Journal …, 2013 - journals.physiology.org
Fibroblast growth factor 23 (FGF23) is a hormone released primarily by osteocytes that regulates
phosphate and vitamin D metabolism. Recent observational studies in humans suggest …
phosphate and vitamin D metabolism. Recent observational studies in humans suggest …
[HTML][HTML] Target engagement imaging of PARP inhibitors in small-cell lung cancer
Insufficient chemotherapy response and rapid disease progression remain concerns for
small-cell lung cancer (SCLC). Oncologists rely on serial CT scanning to guide treatment …
small-cell lung cancer (SCLC). Oncologists rely on serial CT scanning to guide treatment …
Non-invasive PET imaging of PARP1 expression in glioblastoma models
B Carney, G Carlucci, B Salinas… - Molecular imaging and …, 2016 - Springer
Purpose The current study presents [ 18 F]PARPi as imaging agent for PARP1 expression.
Procedures [ 18 F]PARPi was generated by conjugating a 2H-phthalazin-1-one scaffold to 4-[ …
Procedures [ 18 F]PARPi was generated by conjugating a 2H-phthalazin-1-one scaffold to 4-[ …
Dual-modality optical/PET imaging of PARP1 in glioblastoma
Purpose The current study presents [ 18 F]PARPi-FL as a bimodal fluorescent/positron emission
tomography (PET) agent for PARP1 imaging. Procedures [ 18 F]PARPi-FL was obtained …
tomography (PET) agent for PARP1 imaging. Procedures [ 18 F]PARPi-FL was obtained …
Molecular imaging of PARP
The poly(adenosine diphosphate–ribose)polymerase (PARP) family of enzymes is an important
factor in the cellular DNA damage response and has gained much attention for its role in …
factor in the cellular DNA damage response and has gained much attention for its role in …
PARP-1–targeted radiotherapy in mouse models of glioblastoma
SA Jannetti, G Carlucci, B Carney… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is overexpressed in
glioblastoma, with overall low expression in healthy brain tissue. Paired with the availability of …
glioblastoma, with overall low expression in healthy brain tissue. Paired with the availability of …
Physicochemical Properties and Route of Systemic Delivery Control the In Vivo Dynamics and Breakdown of Radiolabeled Gold Nanostars
The in vivo dynamics of nanoparticles requires a mechanistic understanding of multiple
factors. Here, for the first time, the surprising breakdown of functionalized gold nanostars (F‐…
factors. Here, for the first time, the surprising breakdown of functionalized gold nanostars (F‐…
Validation of the use of a fluorescent PARP1 inhibitor for the detection of oral, oropharyngeal and oesophageal epithelial cancers
For oral, oropharyngeal and oesophageal cancer, the early detection of tumours and of residual
tumour after surgery are prognostic factors of recurrence rates and patient survival. Here…
tumour after surgery are prognostic factors of recurrence rates and patient survival. Here…
Investigation of Copper-64-Based Host–Guest Chemistry Pretargeted Positron Emission Tomography
VIJ Jallinoja, BD Carney, K Bhatt… - Molecular …, 2022 - ACS Publications
Pretargeting is a technique that uses macromolecules as targeting agents for nuclear
imaging and therapy with the goal of reducing the radiation toxicity to healthy tissues often …
imaging and therapy with the goal of reducing the radiation toxicity to healthy tissues often …
[HTML][HTML] Development of a clickable bimodal fluorescent/PET probe for in vivo imaging
A Paulus, P Desai, B Carney, G Carlucci, T Reiner… - EJNMMI research, 2015 - Springer
Background Fluorescent imaging agents are becoming evermore important in preclinical
and clinical research. They do, however, suffer from poor tissue penetration, which makes …
and clinical research. They do, however, suffer from poor tissue penetration, which makes …