[PDF][PDF] A kinesin-1 variant reveals motor-induced microtubule damage in cells
BG Budaitis, S Badieyan, Y Yue, TL Blasius… - Current Biology, 2022 - cell.com
Kinesins drive the transport of cellular cargoes as they walk along microtubule tracks; however,
recent work has suggested that the physical act of kinesins walking along microtubules …
recent work has suggested that the physical act of kinesins walking along microtubules …
Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms
The kinesin-3 motor KIF1A functions in neurons, where its fast and superprocessive motility
facilitates long-distance transport, but little is known about its force-generating properties. …
facilitates long-distance transport, but little is known about its force-generating properties. …
Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans
ATY Chen, C Guo, OA Itani, BG Budaitis, TW Williams… - Genetics, 2015 - academic.oup.com
FoxO transcription factors promote longevity across taxa. How they do so is poorly understood.
In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription …
In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription …
Intracellular cargo transport by single-headed kinesin motors
KI Schimert, BG Budaitis… - Proceedings of the …, 2019 - National Acad Sciences
Kinesin motor proteins that drive intracellular transport share an overall architecture of two
motor domain-containing subunits that dimerize through a coiled-coil stalk. Dimerization …
motor domain-containing subunits that dimerize through a coiled-coil stalk. Dimerization …
Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity
BG Budaitis, S Jariwala, DN Reinemann, KI Schimert… - Elife, 2019 - elifesciences.org
10.7554/eLife.44146.001 Kinesin force generation involves ATP-induced docking of the neck
linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, …
linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, …
Single-motor and multi-motor motility properties of kinesin-6 family members
A Poulos, BG Budaitis, KJ Verhey - Biology Open, 2022 - journals.biologists.com
Kinesin motor proteins are responsible for orchestrating a variety of microtubule-based
processes including intracellular transport, cell division, cytoskeletal organization, and cilium …
processes including intracellular transport, cell division, cytoskeletal organization, and cilium …
Differences in single-motor and multi-motor motility properties across the kinesin-6 family
A Poulos, BG Budaitis, KJ Verhey - bioRxiv, 2022 - biorxiv.org
Kinesin motor proteins are responsible for orchestrating a variety of microtubule-based
processes including intracellular transport, cell division, cytoskeletal organization, and cilium …
processes including intracellular transport, cell division, cytoskeletal organization, and cilium …
Developing Future Biologists: creating and assessing a portable short course to engage underrepresented undergraduate students in developmental biology
…, BS Carpenter, JY Martinez-Marquez, BG Budaitis… - bioRxiv, 2018 - biorxiv.org
Many barriers discourage underrepresented students from pursuing science careers. To
access graduate education, undergraduate students must first gain exposure to a particular …
access graduate education, undergraduate students must first gain exposure to a particular …
[PDF][PDF] Pathogenic Mutations in the Kinesin-3 Motor KIF1A Diminish Force Generation and Movement through Allosteric Mechanisms
The kinesin-3 motor KIF1A functions in neurons where its fast and superprocessive motility
is thought to be critical for long-distance transport. However, little is known about the force-…
is thought to be critical for long-distance transport. However, little is known about the force-…
[PDF][PDF] Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor
BG Budaitis, S Jariwala, DN Reinemann - 2019 - core.ac.uk
Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the
motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) …
motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) …