Despite remarkable responses to the tyrosine kinase inhibitor imatinib, CML patients are
rarely cured by this therapy perhaps due to imatinib refractoriness of leukemia-initiating cells (…

To maximize clinical benefits of genetic screening of patients with nephrotic syndrome (NS)
to diagnose monogenic causes, reliably distinguishing NS-causing variants from the …

Trimethylation of histone H3 Lys4 (H3K4) is associated with transcriptional activation. One
of the chief effectors of H3K4 methylation is mixed-lineage leukemia 1 (MLL1), a gene that is …

Background Two genetic variants in apolipoprotein L1 (APOL1) are associated with increased
risk of focal segmental glomerulosclerosis as well as other glomerular phenotypes. These …

Background Lung ultrasound is a well-established technique to assess extravascular lung
water, a proxy for volume status, in the adult population. Despite its utility, the data are limited …

Objective The primary objectives of the study were to describe the association between cardiac
manifestations and in-hospital mortality among children with hemolytic uremic syndrome. …

Background Shiga toxin-producing Escherichia coli (STEC) hemolytic uremic syndrome (HUS)
classically presents with diarrhea. Absence of diarrheal prodrome increases suspicion for …

Background Hospitalization costs for treatment of hemodialysis (HD) catheter-associated
blood stream infections (CA-BSI) in adults are high. No studies have evaluated hospitalization …

In pediatric kidney failure, native kidneys may pose a risk to successful transplant outcomes.
The indications and timing of native nephrectomy represent a controversial management …

Pediatric patients with progressive chronic kidney disease (CKD) approaching kidney
replacement therapy (KRT) make up a small population but carry significant morbidity and mortality…