The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell
growth in response to nutrient, growth, and oncogenic signals. We found that mTORC1 …

Vinculin regulates both cell-cell and cell-matrix junctions and anchors adhesion complexes
to the actin cytoskeleton through its interactions with the vinculin binding sites of α-actinin or …

Purine nucleotides are necessary for various biological processes related to cell proliferation.
Despite their importance in DNA and RNA synthesis, cellular signaling, and energy-…

The mechanistic target of rapamycin (mTOR) serine/threonine kinase, a critical regulator of
cell proliferation, is frequently deregulated in human cancer. Although rapamycin inhibits the …

Bicarbonate (HCO 3 − ) ions maintain pH homeostasis in eukaryotic cells and serve as a
carbonyl donor to support cellular metabolism. However, whether the abundance of HCO 3 − is …

The RAS-ERK/MAPK (RAS-extracellular signal-regulated kinase/mitogen-activated protein
kinase) pathway integrates growth-promoting signals to stimulate cell growth and proliferation…

All cells contain specialized signaling pathways that enable adaptation to specific molecular
stressors. Yet, whether these pathways are centrally regulated in complex physiological …

Cellular purines, particularly adenosine 5′-triphosphate (ATP), fuel many metabolic reactions,
but less is known about the direct effects of pyrimidines on cellular metabolism. We found …

Glycolytic and purine synthesis pathways are often deregulated in therapy-resistant tumors
and can be targeted by the covalent inhibitor described in this study, suggesting its broad …

Biomolecular condensates regulate a wide range of cellular functions from signaling to RNA
metabolism1,2, yet, the physiologic conditions regulating their formation remain largely …