The liver is the largest solid organ in the body and is critical for metabolic and immune
functions. However, little is known about the cells that make up the human liver and its immune …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here we …

Single-cell transcriptomics can profile thousands of cells in a single experiment and identify
novel cell types, states and dynamics in a wide variety of tissues and organisms. Standard …

Adult neural stem cells (NSCs) derive from embryonic precursors, but little is known about
how or when this occurs. We have addressed this issue using single-cell RNA sequencing at …

Liver sinusoidal endothelial cells (LSECs) form a highly specialized microvasculature that
plays a critical role in liver function and disease. To better understand this role, we developed …

Mild traumatic brain injury (mTBI) is an important public health issue, as it can lead to long-term
neurological symptoms and risk of neurodegenerative disease. The pathophysiological …

The transitions from developing to adult quiescent and activated neural stem cells (NSCs)
are not well understood. Here, we use single-cell transcriptional profiling and lineage tracing …

Single-cell RNA sequencing (scRNAseq) represents a new kind of microscope that can measure
the transcriptome profiles of thousands of individual cells from complex cellular mixtures…

Adult neural stem cells (NSCs) reside in two distinct niches in the mammalian brain, the
ventricular-subventricular zone (V-SVZ) of the forebrain lateral ventricles and the subgranular …

Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase (PPIase) that has the potential
to add an additional level of regulation within protein kinase mediated signaling pathways…