Persons suffering from opioid use disorder (OUD) experience long‐lasting dysphoric symptoms
well into extended periods of withdrawal. This protracted withdrawal syndrome is notably …

The United States is experiencing an opioid crisis imposing enormous fiscal and societal
costs and driving the staggering overdose death rate. While prescription opioid analgesics are …

The pedunculopontine nucleus (PPN) is a major component of the reticular activating
system (RAS) that regulates waking and REM sleep, states of high-frequency EEG activity. …

The pedunculopontine nucleus is a part of the reticular activating system, and is active during
waking and REM sleep. Previous results showed that all PPN cells tested fired maximally …

Synaptic efferents from the PPN are known to modulate the neuronal activity of several
intralaminar thalamic regions (eg, the centrolateral/parafascicular; Cl/Pf nucleus). The activation …

Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder
patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) …

The fact that the pedunculopontine nucleus (PPN) is part of the reticular activating system
places it in a unique position to modulate sensory input and fight-or-flight responses. Arousing …

The United States is experiencing an opioid epidemic of significant proportions, imposing
enormous fiscal and societal costs. While prescription opioid analgesics are essential for …

The pedunculopontine nucleus (PPN) is a major component of the reticular activating
system (RAS) that regulates waking and REM sleep, states of high-frequency EEG activity. …

A 10 Hz rhythm is present in the occipital cortex when the eyes are closed (alpha waves), in
the precentral cortex at rest (mu rhythm), in the superior and middle temporal lobe (tau …