Cilia are highly conserved organelles that have diverse motility and sensory functions. Recent
discoveries have revealed that cilia also have crucial roles in cell signaling pathways and …

The zebrafish cloche mutation affects both the endothelial and hematopoietic lineages at a
very early stage (Stainier, DYR, Weinstein, BM, Detrich, HW, Zon, LI and Fishman, MC (1995)…

Forward genetic screens in model organisms are vital for identifying novel genes essential
for developmental or disease processes. One drawback of these screens is the labor-…

Background: Genome editing techniques, including ZFN, TALEN, and CRISPR, have created
a need to rapidly screen many F1 individuals to identify carriers of indels and determine …

Cilia are cell surface organelles found on most epithelia in vertebrates. Specialized groups
of cilia have critical roles in embryonic development, including left–right axis formation. …

The embryonic midline is crucial for the development of embryonic pattern including bilateral
symmetry and left-right asymmetry. In zebrafish, lefty1 (lft1) and lefty2 (lft2) have distinct …

Recently, it has become clear that motile cilia play a central role in initiating a left-sided
signaling cascade important in establishing the LR axis during mouse and zebrafish …

The embryonic midline in vertebrates has been implicated in left-right development, but the
mechanisms by which it regulates left-right asymmetric gene expression and organ …

Notch-mediated induction of Nodal at the vertebrate node is a critical step in initiating left–right
(LR) asymmetry. In mice and zebrafish we show that Baf60c, a subunit of the Swi/Snf-like …

… serotonergic component of the nervous system has been documented in Strongylocentrotus
purpuratus using indirect immunofluorescence with antibodies against serotonin (Bisgrove …