Addictive drugs hijack mechanisms of learning and memory that normally underlie reinforcement
of natural rewards and induce synaptic plasticity of glutamatergic transmission in the …

Cocaine strengthens excitatory synapses onto midbrain dopamine neurons through the
synaptic delivery of GluR1-containing AMPA receptors. This cocaine-evoked plasticity depends …

Dysfunctions of dopaminergic homeostasis leading to either low or high dopamine (DA)
levels are causally linked to Parkinson's disease, schizophrenia, and addiction. Major sites of …

The mesostriatal dopamine (DA) system contributes to several aspects of responses to rewarding
substances and is implicated in conditions such as drug addiction and eating disorders…

Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here,
we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1.3 channel, …

Preclinical evidence suggests an important role of the brain orexin system in behaviours
related to drug addiction. This study aimed at assessing the effect of the orexin-1 receptor …

10.7554/eLife.43551.001 Efficient foraging requires an ability to coordinate discrete reward-seeking
and reward-retrieval behaviors. We used pathway-specific chemogenetic inhibition …

Medication development for cocaine-addicted patients is difficult, and many promising
preclinical candidates have failed in clinical trials. One reason for the difficulty in translating …

Understanding the psychobiological basis of relapse remains a challenge in developing
therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to …

It has been proposed that compulsive drug seeking reflects an underlying dysregulation in
adaptive behavior that favors habitual (automatic and inflexible) over goal-directed (…