A conserved dendritic-cell regulatory program limits antitumour immunity
…, T Marron, AH Rahman, E Kenigsberg, BD Brown… - Nature, 2020 - nature.com
Checkpoint blockade therapies have improved cancer treatment, but such immunotherapy
regimens fail in a large subset of patients. Conventional type 1 dendritic cells (DC1s) control …
regimens fail in a large subset of patients. Conventional type 1 dendritic cells (DC1s) control …
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state
BD Brown, B Gentner, A Cantore, S Colleoni… - Nature …, 2007 - nature.com
We have shown previously that transgene expression can be suppressed in hematopoietic
cells using vectors that are responsive to microRNA (miRNA) regulation. Here we investigate …
cells using vectors that are responsive to microRNA (miRNA) regulation. Here we investigate …
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
…, J LeBerichel, J Nikolic, BM Morales, M Brown… - Nature, 2021 - nature.com
Macrophages have a key role in shaping the tumour microenvironment (TME), tumour
immunity and response to immunotherapy, which makes them an important target for cancer …
immunity and response to immunotherapy, which makes them an important target for cancer …
[PDF][PDF] Immunology of COVID-19: current state of the science
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an …
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an …
Deciphering the transcriptional network of the dendritic cell lineage
Although much progress has been made in the understanding of the ontogeny and function
of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and …
of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and …
[PDF][PDF] GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells
GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is
thought to control the development of inflammatory DCs and resident CD103 + DCs in some …
thought to control the development of inflammatory DCs and resident CD103 + DCs in some …
High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries
We introduce two large-scale resources for functional analysis of microRNA (miRNA): a decoy
library for inhibiting miRNA function and a sensor library for monitoring microRNA activity. …
library for inhibiting miRNA function and a sensor library for monitoring microRNA activity. …
[HTML][HTML] Cancer vaccines: the next immunotherapy frontier
…, GS Lubitz, A Marabelle, I Melero, BD Brown… - Nature cancer, 2022 - nature.com
After several decades, therapeutic cancer vaccines now show signs of efficacy and potential
to help patients resistant to other standard-of-care immunotherapies, but they have yet to …
to help patients resistant to other standard-of-care immunotherapies, but they have yet to …
[HTML][HTML] TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation
Adaptation of the endoplasmic reticulum (ER) pathway for MHC class I (MHC-I) presentation
in dendritic cells enables cross-presentation of peptides derived from phagocytosed …
in dendritic cells enables cross-presentation of peptides derived from phagocytosed …
[PDF][PDF] The cis-regulatory atlas of the mouse immune system
A complete chart of cis-regulatory elements and their dynamic activity is necessary to
understand the transcriptional basis of differentiation and function of an organ system. We …
understand the transcriptional basis of differentiation and function of an organ system. We …