Histone proteins and the nucleosomes they form with DNA are the fundamental building
blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often …

The organization of chromatin into higher-order structures influences chromosome function
and epigenetic gene regulation. Higher-order chromatin has been proposed to be nucleated …

The assembly of higher order chromatin structures has been linked to the covalent modifications
of histone tails. We provide in vivo evidence that lysine 9 of histone H3 (H3 Lys 9 ) is …

… 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1 Brian D. Strahl
… (d) α-H4 R3Me rabbit antiserum was used for an immunoblot analysis of histones isolated …

Recent studies of histone methylation have yielded fundamental new insights pertaining to
the role of this modification in gene activation as well as in gene silencing. While a number of …

Acetylation of core histone tails plays a fundamental role in transcription regulation. In
addition to acetylation, other posttranslational modifications, such as phosphorylation and …

The identification of nuclease-hypersensitive sites in an active globin gene 1 and in the 5′
regions of fruit fly heat shock genes 2 first suggested that chromatin changes accompany …

The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription
initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

Histone methylation is known to be associated with both transcriptionally active and repressive
chromatin states. Recent studies have identified SET domain–containing proteins such …