Technological advances in DNA recovery and sequencing have drastically expanded the
scope of genetic analyses of ancient specimens to the extent that full genomic investigations …

Acinetobacter baumannii is a nosocomial Gram-negative pathogen that often displays
multidrug resistance. Discovering new antibiotics against A. baumannii has proven challenging …

The emergence and spread of carbapenem-resistant Gram-negative pathogens is a global
public health problem. The acquisition of metallo-β-lactamases (MBLs) such as NDM-1 is a …

Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum
and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with …

Although investigations of medieval plague victims have identified Yersinia pestis as the
putative etiologic agent of the pandemic, methodological limitations have prevented large-scale …

The increasing use of polymyxins 1 in addition to the dissemination of plasmid-borne colistin
resistance threatens to cause a serious breach in our last line of defence against multidrug-…

Plasmid-borne colistin resistance mediated by mcr-1 may contribute to the dissemination of
pan-resistant Gram-negative bacteria. Here, we show that mcr-1 confers resistance to colistin…

Shiga toxin-producing Escherichia coli (STEC) strains are commensal bacteria in cattle with
high potential for environmental and zoonotic transmission to humans. Although O157:H7 is …

Addressing the ongoing antibiotic crisis requires the discovery of compounds with novel
mechanisms of action that are capable of treating drug-resistant infections 1 . Many antibiotics …

Salmonella pathogenicity island (SPI)-2 is pivotal to the intracellular survival of Salmonella
and for virulence in mammals. SPI-2 encodes virulence factors (called effectors) that are …