The presence of hepatic steatosis in individuals without a known cause of chronic liver
disease, including excessive alcohol consumption, is the hallmark of nonalcoholic fatty liver …

mRNAs are transported, localized, and translated in axons of sensory neurons. However,
little is known about the full repertoire of transcripts present in embryonic and adult sensory …

The hypothalamus plays a key role in coordinating fundamental body functions. Despite
recent progress in single-cell technologies, a unified catalog and molecular characterization of …

In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …

The mitochondria-targeted quinone MitoQ protects mitochondria in animal studies of pathologies
in vivo and is being developed as a therapy for humans. However, it is unclear whether …

Tumorigenesis involves multistep genetic alterations. To elucidate the microRNA (miRNA)–gene
interaction network in carcinogenesis, we examined their genome‐wide expression …

To facilitate the identification of candidate molecular biomarkers that are linked to the
pathogenesis of hepatocellular carcinoma (HCC), we investigated protein‐expression profiles of …

Background Worldwide, although predominantly in low-income countries in the Middle East
and Africa, up to 13% of hepatitis C virus (HCV) infections are caused by HCV genotype 4. …

Context: Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of
somatic KCNJ5 mutations suggests a genetic explanation. Objectives: The objectives of this …

More than one-half billion people are obese, and despite progress in genetic research,
much of the heritability of obesity remains enigmatic. Here, we identify a Trim28-dependent …