The identification of ultraconserved noncoding sequences in vertebrates has been associated
with developmental regulators and DNA-binding proteins. One of the first of these was …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity …

The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification. …

Comprehensive analysis of the mammalian transcriptome has revealed that long non-coding
RNAs (lncRNAs) may make up a large fraction of cellular transcripts. Recent years have …

The optic vesicle comprises a pool of bi-potential progenitor cells from which the retinal
pigment epithelium (RPE) and neural retina fates segregate during ocular morphogenesis. …

Elevated levels of low‐density lipoprotein cholesterol (LDL‐C) in plasma are a major
contributor to cardiovascular disease, which is the leading cause of death worldwide. Genome‐…

Analysis of gene expression in single cells allows for decomposition of cellular states as low-dimensional
latent spaces. However, the interpretation and validation of these spaces …

Genes encoding cell-surface proteins control nervous system development and are implicated
in neurological disorders. These genes produce alternative mRNA isoforms which remain …

Gene regulatory networks (GRNs), consisting of transcription factors and their target sites,
control neurogenesis and cell-fate specification in the developing central nervous system. In …

Transcription-regulating long non-coding RNAs (lncRNAs) have the potential to control the
site-specific expression of thousands of target genes. Previously, we showed that Evf2, the …