We have determined that Borrelia burgdorferi strain B31 MI carries 21 extrachromosomal
DNA elements, the largest number known for any bacterium. Among these are 12 linear and …

In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia
burgdorferi, has risen from relative obscurity to become a global public health problem and a …

While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic alterations
during tumorigenesis including aberrant DNA hypermethylation of tumor suppressors, …

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …

We performed exome sequencing to detect somatic mutations in protein-coding regions in
seven melanoma cell lines and donor-matched germline cells. All melanoma samples had …

We conducted a pilot clinical trial testing a personalized vaccine generated by autologous
dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC), which …

Cancer/Testis (CT) genes, normally expressed in germ line cells but also activated in a wide
range of cancer types, often encode antigens that are immunogenic in cancer patients, and …

Background Glycaemic control is a key issue in the care of people with diabetes mellitus (DM).
Periodontal disease is the inflammation and destruction of the underlying supporting …

Previous studies have demonstrated that Borrelia burgdorferi in the midguts of infected ticks
shows increased expression of the antigenic outer surface protein OspC after the ticks have …

One key barrier to improving efficacy of personalized cancer immunotherapies that are
dependent on the tumor antigenic landscape remains patient stratification. Although patients with …